| 虫草素的抗肿瘤与抗转移作用的研究进展 |
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| 引用本文： | 崔琳琳, 袁甜, 王洋, 李洋, 申光焕. 虫草素的抗肿瘤与抗转移作用的研究进展[J]. 食品工业科技, 2021, 42(4): 356-362. DOI: 10.13386/j.issn1002-0306.2020040172 |
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| 作者姓名： | 崔琳琳 袁甜 王洋 李洋 申光焕 |
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| 作者单位： | 1.1. 哈尔滨商业大学药学院, 黑龙江哈尔滨 150076 |
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| 基金项目： | 黑龙江省留学回国人员择优资助项目(18930101);哈尔滨商业大学青年创新人才项目(17XN031);哈尔滨商业大学博士科研启动项目(2019DS116)。 |
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| 摘 要： | 癌症为死亡第一大杀手,虫草素可以抑制肿瘤细胞的增殖与迁移,具有副作用小、耐药性高等优点.近几年利用现代计算机技术寻找其抗肿瘤机制和潜在的生物靶点将会为挖掘虫草素抗肿瘤机制开辟新的天地,极大地推进虫草素在抗肿瘤方面的应用.虫草素不仅通过调节与肿瘤相关的信号通路来诱导细胞凋亡,造成周期停滞,靶向干预肿瘤干细胞(CSCs)抑...
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| 关 键 词： | 虫草素 抗肿瘤 周期阻滞 凋亡 抗转移 分子生物学 |
| 收稿时间： | 2020-04-15 |
Research Progress of Anti-tumor and Anti-metastasis Effects of Cordycepin |
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| CUI Linlin, YUAN Tian, WANG Yang, LI Yang, SHEN Guanghuan. Research Progress of Anti-tumor and Anti-metastasis Effects of Cordycepin[J]. Science and Technology of Food Industry, 2021, 42(4): 356-362. DOI: 10.13386/j.issn1002-0306.2020040172 |
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| Authors: | CUI Linlin YUAN Tian WANG Yang LI Yang SHEN Guanghuan |
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| Affiliation: | 1.1. Harbin University of Commerce College of Pharmacy, Harbin 150076, China |
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| Abstract: | Cancer is the number one killer of death,cordycepin can inhibit the proliferation and migration of tumor cell,and has the advantages of small side effects and high drug resistance.In recent years,the use of modern computer technology to find its anti-tumor mechanism and potential biological targets will open up a new horizons for the exploration of cordycepin’s anti-tumor mechanism and greatly promote the application of cordycepin in anti-tumor.Cordycepin not only induces apoptosis by regulating tumor-related signaling pathways,causes cycle arrest,targeted intervention of tumor stem cells(CSCs)inhibits tumor growth,and also inhibits tumor metastasis by regulating the tumor microenvironment.The contents of this review will provide a reference that is for better research on the antitumor mechanism of cordycepin in later period. |
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| Keywords: | cordycepin anti-tumor cycle arrest apoptosis anti-metastasis molecular biology |
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