| 抗癫痫1,2,4-三氮唑类衍生物研究进展 |
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| 引用本文： | 耿延汝,丁静,黄龙江. 抗癫痫1,2,4-三氮唑类衍生物研究进展[J]. 精细化工, 2019, 36(3): 361-367 |
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| 作者姓名： | 耿延汝 丁静 黄龙江 |
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| 作者单位： | 青岛科技大学 化工学院,山东 青岛,266042;青岛科技大学 化工学院,山东 青岛 266042;中国医学科学院北京协和医学院 药物研究所,天然药物活性物质与功能国家重点实验室,北京 100050 |
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| 基金项目： | 天然药物活性物质及与功能国家重点实验室开放课题资助项目(GTZK201805)；山东省高校科技计划项目资助项目(J16LC13). |
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| 摘 要： | 根据含1,2,4-三氮唑结构单元化合物的结构特点,总结了并环类和非并环类抗癫痫药物活性方面的研究进展,重点分析了不同结构类型与其抗癫痫活性以及神经毒性之间的关系。得出结论,1,2,4-三氮唑并喹啉、喹唑啉衍生物和三氮唑硫酮衍生物因具有良好的活性、较低的毒性从而具有进一步研究和开发的价值;在此基础上,对1,2,4-三氮唑类化合物抗癫痫活性未来的研究方向进行了展望。
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| 关 键 词： | 1 2 4-三氮唑 抗癫痫活性 神经毒性 |
| 收稿时间： | 2018-06-27 |
| 修稿时间： | 2018-11-26 |
Progress in 1,2,4-Triazole Derivatives with Antiepileptic Activity |
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| gengyanru,dingjing and huanglongjiang. Progress in 1,2,4-Triazole Derivatives with Antiepileptic Activity[J]. Fine Chemicals, 2019, 36(3): 361-367 |
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| Authors: | gengyanru dingjing huanglongjiang |
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| Affiliation: | College of Chemical Engineering, Qingdao University of Science and Technology,College of Chemical Engineering, Qingdao University of Science and Technology |
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| Abstract: | According to the structural characteristics of compounds containing 1,2, 4-triazole moiety, the research progress on antiepileptic activities of fused heterocyclic and non-fused heterocyclic compounds is summarized. The relationship between different structural types with antiepileptic activities and neurotoxicity is emphatically analyzed. It is concluded that 1,2,4-triazole fused quinoline derivatives, quinazoline derivatives and triazole thione derivatives are valuable for further research and development due to their good activity and low toxicity. Finally, the future research directions of 1,2,4-triazole derivatives with antiepileptic activity are prospected. |
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| Keywords: | 1,2,4-triazole anticonvulsant activity neurotoxicity |
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