Synthesis of Gonadoliberin,a gonadotropin releasing hormone |
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Authors: | Barbara Rzeszotarska Elzbieta Masiukiewicz Halina Kmiecik-Chmura |
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Abstract: | A simple laboratory synthesis of gonadoliberin was elaborated basing on classical solution methods and using minimal protection of side-chain functions. In the final step a hexapeptide segment was condensed with the corresponding tetrapeptide and the obtained product was purified by a single step silica gel chromatography. The total efficiency of the whole synthesis was 15%. |
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