He－Ne激光照射、免疫抑制剂及二者配合应用对大鼠全胰十二指肠移植的影响

以Ａｌｌｏｘａｎ糖尿病模型大鼠作为受体，健康雄性大鼠为供体，行全胰十二指肠移植术，观察了Ｈｅ－Ｎｅ激光照射、免疫抑制剂及二者配合应用抗移植排斥反应的作用效果。结果表明，日剂量为３９．７２Ｊ／ｃｍ２的Ｈｅ－Ｎｅ激光照射，可推迟排斥反应的发生时间、降低排斥反应的发生程度及延长大鼠全胰十二指肠移植物的存活时间。激光照射与８－５－３ｍｇ／ｋｇ／ｄａｘ的硫唑嘌呤（Ａｚａ）配合应用，具有相加的效果，上述作用更为显著，且与环孢霉素Ａ（ＣｓＡ）的作用效果接近。

The Effects of He-Ne Laser Irradiation, Immune Inhibitors and Their Combination Upon the Transplantation of Pancreas with Duodenum in Wistar Rats

Pancreas with duodenum was transplanted from healthy, male rats to the artificially diseased male rats of alloxan diabetes. He- Ne laser irradiation, immune inhibitors and their combination were applied immediately after the operation to observe their effects against rejection. The results are as follows: with the treatment of He-Ne laser irradiation at a dose of 39. 72 J/cm2, the starting time of rejection to the organs was delayed, the living time of the organs was prolonged and the intensity of rejection was lightened. The above saated effects can be stronger when laser irradiation is combined with medication of azathioprin (at the dose of 8-5-3 mg/kg/day) and the effects are colse to those of cydosporin A(CsA).