Cyclin D1和bcl-2在B细胞淋巴瘤中的表达及其在鉴别诊断中的意义

B细胞淋巴瘤根据免疫表型可分为不同亚型,且不同亚型侵袭度不同,预后也有很大差异.Cyclin D1是已被证实与肿瘤有最直接关系的细胞周期蛋白,在大多B细胞淋巴瘤套细胞淋巴瘤(MCL)、慢性淋巴细胞白血病(CLL)、边缘区淋巴瘤(MZL)、弥漫大B细胞淋巴瘤(DLBCL)等」中均有表达.多数B细胞淋巴瘤滤泡性淋巴瘤(FL)、DLBCL等]都能可见易位活化的bcl-2表达增强.Cyclin D1及bcl-2作为B细胞淋巴瘤重要的细胞周期蛋白及抗凋亡基因,在淋巴瘤的鉴别诊断中起重要作用,其检测及检测手段的灵敏度和特异度具有重要的临床价值.

Significance of Cyclin D1 and bcl-2 expression in the diagnosis of B cell lymphoma

Based on the immunophenotype, B cell lymphoma can be distinguished into different isoforms, which have different incursions. Cyclin D1 has been detected in a wide variety of lymphoid and myeloid malignancies, which expression in B-cell tumors on an expanded group of lymphomas that included MCL, B-CLL, diffuse large B-cell lymphomas (DLBCL), marginal zone lymphoma (MZL), reactive hyperplasia group. Bcl-2 itself is highly expressed in the majority of B-cell lymphomas follicular lymphoma (FL), DLBCL].Both of them play an important role in differential diagnosis of B cell lymphoma. So its sensitivity and specificity of test facility have crucial clinical value.