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Platelet-activating factor may mediate dexamethasone-induced gastric damage in the rat
Authors:János Filep  Ferenc Hermán  Pierre Braquet
Affiliation:(1) Department of Pathophysiology, Semmelweis University Medical School, 1445 Budapest, Hungary;(2) Department of Pharmacodynamics, Semmelweis University Medical School, 1445 Budapest, Hungary;(3) Institut Henri Beaufour, 92350 Le Plessis Robinson, France;(4) Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, J1H 5N4 Sherbrooke, Quebec, Canada
Abstract:The possible role of platelet-activating factor (PAF) in dexamethasone-induced gastric mucosal damage was studied in rats. PAF was measured by a platelet aggregation assay. The identity of the PAF-like product recovered from gastric tissues was ascertained by thin-layer chromatography and high-pressure liquid chromatography. Low levels of PAF were detected in the normal rat stomach, while in dexamethasone-treated animals PAF levels were significantly higher. Pretreatment of the animals with BN 52021, a specific PAF receptor antagonist, significantly attenuated dexamethasone-induced mucosal injury. These findings suggest that PAF may be a mediator of mucosal damage induced by glucocorticoids. Based on a paper presented at the Third International Conference on Platelet-Activating Factor and Structurally Related Alkyl Ether Lipids, Tokyo, Japan, May 1989.
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