A Ser315Thr substitution in KatG is predominant in genetically heterogeneous multidrug-resistant Mycobacterium tuberculosis isolates originating from the St. Petersburg area in Russia |
| |
| Authors: | HJ Marttila H Soini E Eerola E Vyshnevskaya BI Vyshnevskiy TF Otten AV Vasilyef MK Viljanen |
| |
| Affiliation: | Mycobacterial Reference Laboratory, National Public Health Institute, Kiinamyllynkatu 13, 20520 Turku, Finland. harmar@utu.fi |
| |
| Abstract: | Parts of katG and rpoB from 27 Russian Mycobacterium tuberculosis isolates were sequenced to detect mutations causing resistance to isoniazid (INH) and rifampin (RMP), respectively. All 24 INH-resistant isolates had a mutated katG, and 22 of them (91.7%) carried a mutation coding for a Ser315Thr shift. An rpoB mutation was noted for each of the 21 RMP-resistant isolates, with Ser531Leu being the most prevalent change encoded. Only two isolates had identical IS6110 fingerprints. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
