半自动化合成N-琥珀酰亚胺-4-18F-氟苯甲酸酯

通过对现有半自动化学合成模块（CPCU）的改造，以乙基-4-三甲胺苯甲酸酯-三氟磺酸盐为反应前体合成用于标记蛋白质、抗体及多肽等牛物分子的辅助基团N-琥珀酰亚胺-4-18F-氟苯甲酸酯（18F-SFB），产物用高效液市H色谱（HPLC）进行检测。合成过程在80min内完成，校正后得到中间产物18F-FBA，产率为80％±5％（n=8），而终产品18F-SFB总衰变校正后的放化收率为40％±5％（n=20），放化纯度≥99％。利用CPCU半自动化合成18F-SFB，方法简便，产率稳定。该法为将来多肽等生物分子的，SF标记提供了依据。

Radiosynthesis of N-succunimidy-4-18F-fluorobenzoate Using Siemens Chemistry Process Control Unit

The objective of this research was to synthesize the N-succunimidy-4-18F- Fluorobenzoate (18F-SFB), which is used as the prosthetic groups for the 18F labeling of bimolecular like proteins, mono-antibodies and peptides, using the modified Chemistry Process Control Unit (CPCU). The CPCU was modified, we synthesized 18F-SFB using the ethyl-4-trimethyammonium-benzoate triflate as precursor. And the radiochemical purity of the products was measured by High Performance Liquid Chromatograph (HPLC). The total synthesis time was 80 min after EOB. The decay-corrected radiochemical yield of 18F-FBA was 80±5% (n=8) and that of 18F-SFB was 40±5 % (n＝20) . The radiochemical purity was more than 99%. Thus, 18F-SFB can be conveniently synthesized with modified CPCU and the labeling yield was stable, which was easily used for the labeling of bioactive compounds.