| 乙酰氨基丙二酸二乙酯合成新工艺研究 |
| |
| 引用本文： | 屈彬,范淑辉,赵德丰. 乙酰氨基丙二酸二乙酯合成新工艺研究[J]. 化学世界, 2002, 43(11): 587-589 |
| |
| 作者姓名： | 屈彬 范淑辉 赵德丰 |
| |
| 作者单位： | 鞍山热能研究院,辽宁,鞍山,114004;西昌师范专科学校化学系,四川,西昌,615002;大连理工大学精细化工国家重点实验室,辽宁,大连,116012 |
| |
| 摘 要： | 以丙二酸二乙酯、冰醋酸、亚硝酸钠为原料 ,n( CH2 - ( COOC2 H5) 2 )∶ n( CH3 COOH)∶n( Na NO2 ) =1∶ 2∶ 2 ,加入相转移催化剂合成肟基丙二酸二乙酯 ( DEOM) ,节省冰醋酸和亚硝酸钠的使用量。 DEOM用 CH2 Cl2 萃取 ,然后将 DEOM在 40～ 5 0℃、醋酸介质中加锌粉还原 ,乙酐酰化 ,用水结晶得产品乙酰氨基丙二酸二乙酯 ( DEAM) ,熔点 96.5～ 97.5℃ ,相对于丙二酸二乙酯收率为 79.6%。
|
| 关 键 词： | 肟基丙二酸二乙酯 相转移催化 乙酰氨基丙二酸二乙酯 |
| 文章编号： | 0367-6358(2002)11-0587-03 |
Study on the Synthesis of Diethyl Acetamidomalonate |
| |
| QU Bin ,FAN Shu hui ,ZHAO De feng. Study on the Synthesis of Diethyl Acetamidomalonate[J]. Chemical World, 2002, 43(11): 587-589 |
| |
| Authors: | QU Bin FAN Shu hui ZHAO De feng |
| |
| Affiliation: | QU Bin 1,FAN Shu hui 2,ZHAO De feng 3 |
| |
| Abstract: | Diethyl oximinomalonate(DEOM) was prepared from diethyl malonate, glacial acetic acid and sodium nitrite with n (CH 2(COOC 2H 5) 2)∶ n HAC∶ n (NaNO 2)=1∶2∶2 in the presence of phase transfer catalyst so as to save HAc and NaNO 2. DEOM was extracted with CH 2Cl 2. Diethyl acetamidomalonate was obtained by reducing DEOM with Zn powder and acylating with (Ac) 2O in HAc medium at 40～50℃. The product was crystallized in water. The yield of the title compound was 79.6% , and its mp. was 96.5 ～ 97.5 ℃. |
| |
| Keywords: | diethyl oximinomalonate phase transfer catalyst diethyl acetamidomalonate |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
