Nanomodulators Capable of Timely Scavenging ROS for Inflammation and Prognosis Control Following Photothermal Tumor Therapy |
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Authors: | Shuai Wang Jixi Huang Hanyin Zhu Jing Zhu Zhenqiang Wang Yuxin Xing Xiyue Xie Kaiyong Cai Jixi Zhang |
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Affiliation: | Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, No. 174 Shazheng Road, Chongqing, 400044 China |
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Abstract: | Despite the accuracy advantages of photothermal therapy (PTT), heat stress-initiated free radicals and damage-activated immune cells form a malignant positive feedback cycle following light irradiation. Herein, a 2D allomelanin nanomodulator with perpendicularly oriented oligomer planes is prepared by the guidance of DNA to achieve timely scavenging of reactive oxygen species (ROS) for inflammation and prognosis control following PTT. A large exposure degree of phenol groups and the effective transfer of delocalized electrons result in ultra-fast redox reactions that can be boosted by a self-amplifying process through structure disintegration. Compared with conventional photothermal agents, the nanodisks reduce the accumulation of ROS during PTT by 25-fold, downregulate the proinflammatory factors, and adjust inflammation levels to baseline. Thereby, successful modulation of M2-type macrophages in paratumor tissues significantly prevents burn wound progression and accelerates tissue repair, while well-controlled neutrophil extracellular traps and largely recruited CD4+/CD8+ T cells (1.6–3.2-fold) in the ablation site suppress the relapse of distant tumors. The study provides a useful inspiration on rationally modulating redox active nanostructures to address prognosis issues following PTT. |
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Keywords: | inflammation  controls photothermal  therapy redox  nanostructures ROS  scavenging stress  responses |
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