| 转染结构性雄烷受体CAR对MMC和629的辐射增敏性的影响 |
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| 引用本文： | 张江虹,郝福荣,金一尊.转染结构性雄烷受体CAR对MMC和629的辐射增敏性的影响[J].核技术,2008,31(8). |
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| 作者姓名： | 张江虹 郝福荣 金一尊 |
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| 作者单位： | 1. 复旦大学放射医学研究所,上海,200032
2. 潍坊市人民医院,潍坊,261041 |
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| 摘 要： |
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| 关 键 词： | 629 丝裂霉素C 乏氧 辐射增敏效应 结构性雄烷受体 |
Effect of constitutive androstane receptor on radiosensitization of mictomycin C and its homologoue-629 |
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| ZHANG Jianghong,HAO Furong,JIN Yizun.Effect of constitutive androstane receptor on radiosensitization of mictomycin C and its homologoue-629[J].Nuclear Techniques,2008,31(8). |
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| Authors: | ZHANG Jianghong HAO Furong JIN Yizun |
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| Abstract: | The object of this work is to evaluate radiosensitization of MMC and its analogue 5-(aziridin-1-yl)-3- hydroxymethyl-1-methylindole-4,7-dione(629) and how transfection of constitutive androstane receptor (CAR) affect their biological effects. The expressions of CAR mRNA and CYP2B6 mRNA in HepG2 cells and g2car cells were detected by RT-PCR. The radiosensitization of MMC and 629 in vitro were evaluated in HepG2 cells and g2car cells by colony formation under anaerobic and aerobic condition. The effect of 629... |
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| Keywords: | 629 MMC Hypoxia Radiosensitization Consititutive androstane receptor |
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