| 头孢西丁钠的合成 |
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| 引用本文： | 赵振华,杜海生,汤沸,王勇进.头孢西丁钠的合成[J].山东化工,2008,37(12). |
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| 作者姓名： | 赵振华 杜海生 汤沸 王勇进 |
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| 作者单位： | 齐鲁安替制药有限公司,山东,济南,250105 |
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| 摘 要： | 头孢西丁是一种具有长效、广谱抗菌特点的第二代头孢类抗生素。本文以头孢噻吩酸为原料,甲氧基化产物不需结晶提纯而直接用于去乙酰化,缩短了生产周期和节省了原料。本方法制备简便,适于工业化生产。
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| 关 键 词： | 头孢噻吩 头孢西丁钠 合成 次氯酸叔丁酯 异辛酸钠 |
Synthesis of Cefoxitin Sodium |
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| ZHAO Zhen-hua,DU Hai-sheng,TANG Fei,WANG Yong-jin.Synthesis of Cefoxitin Sodium[J].Shandong Chemical Industry,2008,37(12). |
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| Authors: | ZHAO Zhen-hua DU Hai-sheng TANG Fei WANG Yong-jin |
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| Abstract: | Cefoxitin,the second-generation cephalosporins,is permanence and has a broad spectrum of antibacterial activity.In this paper,starting from cephalotin,the cefoxitin was obtained via 3 steps including methoxylation,deacetylation and carbamoylation.The poduct of methoxylation could be used for deacetylation without crystallition and purification,and the materials were redused and production cycle was shorten.The method is simple and convenient and can be scaled up to indusrtrial production. |
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| Keywords: | cephalotin cefoxitin sodium synthesis tert-butyl hypochlorite sodium 2-ethylhexanoate |
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