Molecular recognition in chiral discrimination |
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| Affiliation: | 1. Department of Chemistry, University of Pretoria, Pretoria 0002, South Africa;2. Pharmaceutical Analysis Laboratory, Biological and Medical Research Department (MBC-03), King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, Saudi Arabia;1. Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia;2. Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India;3. Department of Chemistry, College of Sciences, Taibah University, Al-Medina Al-Munawara 41477, Saudi Arabia;1. Tianjin Key Laboratory of Brine Chemical Engineering and Resource Eco-utilization, College of Chemical Engineering and Materials Science, Tianjin University of Science & Technology, Tianjin 300457, PR China;2. College of Chemistry and Environmental Science, Hebei University, Hebei Baoding 071002, PR China;3. National Center for Nanoscience and Technology, Beijing 100190, PR China;1. Advanced Catalysis and Green Manufacturing Collaborative Innovation Center, School of Petrochemical Engineering, Changzhou University, Changzhou, 213164, China;2. Jiangsu Provincial Key Lab of Palygorskite Science and Applied Technology, Huaiyin Institute of Technology, Huaian, 223003, China |
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| Abstract: | The importance of obtaining reliable detection systems for enantiomers' assays increases with the necessity of chiral discrimination between the enantiomers of raw materials from the pharmaceutical industry. The utilization of electrochemical sensors in molecular recognition of chiral substances becomes a very accurate and precise alternative for the structural analysis as well as for the chromatographic techniques. The reliability of the response characteristics as well as of the analytical information obtained by using electrochemical sensors is strictly correlated with the design of the sensors. The most reliable design is that of carbon paste based sensors; this design was adopted for the construction of potentiometric, enantioselective membrane electrodes as well as for the construction of the amperometric biosensors, and immunosensors. However, it is also necessary to look for more reliable chiral selectors. |
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