TLR7和AP-1在基底细胞癌中的表达及意义

目的：观察基底细胞癌中TLR7和AP-1蛋白的表达，探讨二者与基底细胞癌发生发展的关系。方法：收集基底细胞癌患者皮损30例及正常人皮肤组织26例，采用免疫组织化学法检测癌组织中TLR7和AP—1蛋白的表达水平；分析TLR7和AP-1在基底细胞癌中的表达水平以及二者之间的相互关系。结果：TLR7和AP-1在癌组织中表达均较正常皮肤组织高（P〈0．05），表达水平与性别、年龄均无差异（P〉0．05）；TLR7和AP-1在基底细胞癌中的蛋白表达水平成明显正相关（r=0．78，P〈0．01）。结论：TLR7和AP-1蛋白在基底细胞癌中高表达，且二者的表达水平呈明显正相关；TLR7和AP-1可能与基底细胞癌的发生发展有关。

Expression and significance of TLR7and AP- 1 in basal cell carcinoma

Objective： To investigate the expression of TLR7 and AP- 1 in basal cell carcinoma, and to explore their possibihties oi occurrence and development. Method The expression of TLR7 and AP - 1 were detected in 30 cases of basal cell carcinoma and 26 cases of normal tissue . Specimens were detected by immunohistochemistry. Result Immunohistochemistry showed that TLR7 and AP - 1 were both highly expressed in tumor tissue （ P 〈 0.05 } and the expression of TLR7 and AlP - 1 in luaror tissue were significant positive correlation（ r ~- 0.78, p 〈 0.01 }. But the both expression were not statistically difference with gende and age （ P 〉 O. 05 ）. Conclusion TLR7 and AP - 1 were highly expressed in basal cell carcinoma, and their expression level was significant positive correlation. These results suggested the TLR7 and AP- 1 gene may play important roles in basal cell carcinoma occurrence and development.