Copper-Catalyzed Dehydration of Primary Amides to Nitriles |
| |
Authors: | Stephan Enthaler Maik Weidauer |
| |
Affiliation: | 1.Department of Chemistry, Cluster of Excellence Unifying Concepts in Catalysis,Technische Universit?t Berlin,Berlin,Germany |
| |
Abstract: | Abstract In the present study we introduce a copper-catalyzed protocol for the dehydration of primary amides to their corresponding
nitriles applying N-methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) as silylation reagent. For that purpose investigations of various reaction parameters
(copper source, solvent, temperature, MSTFA and copper loading) have been carried out to find suitable reaction conditions.
Simple copper(I) chloride (2.5 mol%) and MSTFA (2.0 equiv) in toluene allow for the straightforward synthesis of a variety
of nitriles (15 examples). |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|