| 尼群地平的绿色的合成工艺研究 |
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| 引用本文： | 周行知,章清龙,徐立,牛立慧,史达清. 尼群地平的绿色的合成工艺研究[J]. 化工时刊, 2006, 20(6): 32-33 |
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| 作者姓名： | 周行知 章清龙 徐立 牛立慧 史达清 |
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| 作者单位： | 徐州师范大学化学系,江苏,徐州,221116;徐州师范大学化学系,江苏,徐州,221116;江苏省药用植物生物重点技术实验室,江苏,徐州,221116 |
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| 摘 要： | 以间硝基苯甲醛,乙酰乙酸乙酯,氨化试剂为原料。考察了氨化试剂,催化剂,温度对产物的影响,确定了最佳反应条件所得的尼群地平产率达到了98%。并用红外和核磁共振对产物的结构进行了表征。本方法具有环境友好,产率高,反应时间短等优点。
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| 关 键 词： | 尼群地平 合成 水相应条件 |
| 收稿时间： | 2005-12-28 |
| 修稿时间： | 2005-12-28 |
Studies on the Green Procedure for the Synthesis of Nefedipine |
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| Zhou Xingzhi,Zhang Qinglong,Xu Li,Nui Lihui,Shi Daqing. Studies on the Green Procedure for the Synthesis of Nefedipine[J]. Chemical Industry Times, 2006, 20(6): 32-33 |
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| Authors: | Zhou Xingzhi Zhang Qinglong Xu Li Nui Lihui Shi Daqing |
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| Affiliation: | 1 Department of Chemistry, Xuzhou Normal University, Jiangsu Xuzhou 221116; 2 .The Key Laboratory of Biotechnology for Medical Plants of Jiangsu Province Jiangsu Xuzhou 221116 |
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| Abstract: | Nefedipine was synthesized with m-Nitrobenzaldehyde,ethyl acetoacetate,ammonium acetate.The influence of ammoniation reagent,catalyst,temperature mixing on the product yield was observed.The maxium yield of Nefidipine was 98%.The product was characterized with IR and ~1 H NMR spectrometer.This new method has advantages of environmental friendly,high yield,short reaction time. |
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| Keywords: | nefedipine synthesis water |
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