微孔致孔剂对钙磷陶瓷表面类骨磷灰石形成的研究

钙磷陶瓷表面类骨磷灰石层的形成对瓷诱导新骨生成起非常重要的作用. 本文利用体外模拟装置首次研究了微孔致孔剂对新工艺制备的含CO₃^2-的双相HA/β-TCP多孔陶瓷表面类?骨磷灰石形成的影响. 结果表明, 该陶瓷因CO₃^2-的掺入, 导致类骨磷灰石晶体的形成时间大大缩短(从14天缩短至6天). 此外还有缺钙羟基磷灰石晶体?的生成. 并且微孔致孔剂以聚乙烯醇缩丁醛(PVB)优于硬脂酸(SA)粉末, 它更有?利于类骨磷灰石的形成. 在同时加入PVB作微孔致孔剂时, 类骨磷灰石晶体的形成情况随PVB加入量的增大而越来越好. 综合其相关性能来看, PVB的加入量以m_钙磷粉:m _致孔剂=1:0.3为宜. 微孔致孔剂的优化有利于该陶瓷材料骨诱导性的提高.

Effects of Micropore Porosifer on the Formation of Bone-like Apatite in the Calcium Phosphate Ceramics

The formation of the bone-like apatite containing carbonate in the calcium phosphate ceramics is important to the growth of the new bone and the osteoinductivity of the materials. The effect of the micropore porosifer on the formation of the bone-like apatite in carbonate-contained HA/β-TCP ceramics prepared by the new technique was discussed in detail for the first time. The results show that the bone-like apatite can be formed in shorter time (about 6 days) in this ceramics for the carbonate mixing into the structure of the apatite crystal. The results also show that the ceramics with the PVB micropore porosifer lead to the better bone-like apatite formation compared with the SA micropore porosifer, and the best ratio is m_{calcium phosphate powder}:m_PVB=1:0.3. The optimization of the micropore porosifer is good to improving the osteoinductivity of the carbonate-contained HA/β-TCP ceramics, which is great help to the restoration of the bone defect.