蜂胶复合胶囊毒理学的动物实验观察

目的:蜂胶复合胶囊为蜂胶与中药组成的复方制剂,为了判断其对人体健康是否产生危害,特进行了安全性毒理学评价。方法:急性毒性半数致死量(LD50)实验,小鼠骨髓细胞微核实验,精子畸变实验,Ames 实验,30d 喂养实验。结果:该胶囊经急性毒性半数致死量(LD50)实验,数据显示,该胶囊无毒,三项致突实验均为阴性结果,在传统致畸实验中未见大鼠发育毒性和胚胎毒性,在30d 喂养实验中也无异常发现。结论:蜂胶复合胶囊临床使用安全可靠。

Toxicological Assessment of Propolis Complex Capsule in Mice

Objective: Propolis complex capsule was a kind of constituent of herbal medicine by means of tradition propolis compounded preparation. It was necessary to make the toxicological assessment. Methods: The acute toxicity LD50 test in mice, micronuclei test of bone marrow cell and sperm shape abnormality test and chromosome malformation analysis of testicle reproductive cell were assyed with Ames test and 30d feeding test in mice. Result: According to the result of acute toxicity LD50 test in mice, the Propolis complex capsule showed no acute toxicity. All three genotoxicity tests were negative. The develop- mental toxicity and embryotoxicity had also not been found in teratogenicity test.Abnormal phenomena had not been found in 30d feeding test.Conclusion: Propolis complex capsule was safe in use.