A sustained folic acid release system based on ternary magnesium/zinc/aluminum layered double hydroxides |
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Authors: | Rong Xiao Wenrui Wang Longlong Pan Rongrong Zhu Yongchun Yu Huiping Li Hui Liu Shi-Long Wang |
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Affiliation: | (1) Tenth People’s Hospital, School of Life Science and Technology, Shanghai Pulmonary Hospital, Tongji University, 1239 Siping Road, Shanghai, 200092, People’s Republic of China;(2) Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, People’s Republic of China; |
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Abstract: | This study first synthesized and characterized the ternary magnesium/zinc/aluminum layered double hydroxides (Mg/Zn/Al-LDHs)
intercalated with folic acid. We prepared the ternary (Mg, Zn, Al) LDH carrier by the introduction of zinc, because magnesium
and zinc are both vital minerals of human body. The nanohybrids were prepared by the method of coprecipitation and were characterized
by powdered sample X-ray diffraction (XRD), Fourier transform infrared spectra (FT-IR), UV–vis spectra, and MTT assay. The
loading amount of intercalated folic acid was increased to 45.2%, and showed a profile of sustained release with 75% in 250 min.
In addition, the folic acid-LDH nanohybrids showed an enhanced thermal stability and a profound buffering property, which
demonstrated that the hybrids could protect folic acid against heat degradation and prompt its available diffusion. The cell
viability of HEK293T was over 80% after treated with nanohybrids for 72 h. Our results suggested that the ternary folic acid-LDH
nanohybrids may function as a useful nutritional tablet to promote the bioavailability of folic acid delivery. |
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