| Abstract: | In 4 experiments, male Sprague-Dawley rats made diabetic by an intravenous injection of streptozotocin (65 mg/kg) showed decreased stereotyped behaviors following subcutaneous (sc) administration of apomorphine HCL (1 mg/kg) or dextro-amphetamine sulfate (3 mg/kg). Spontaneous activity in an open field was lower in diabetics than in controls, but a low dose (25 μg/kg, sc) of apomorphine produced equivalent fractional decreases in activity in both groups. In vivo accumulation of amphetamine and apomorphine was generally similar in both groups: Reduced tissue access did not appear to be responsible for the decreased behavioral effects of these agents. The in vivo accumulation of spiroperidol in several brain regions was generally less in diabetics than in controls. Data are discussed in terms of altered catecholamine biochemistry and behavior in diabetics. (30 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) |
