| Abstract: | Intraperitoneal cholecystokinin octapeptide (CCK-8 0.1–5 μg/kg]) reduced feeding in Syrian hamsters in a dose-related fashion, except for males tested during the light phase of the illumination cycle. Proglumide (200 or 400 mg/kg), a putative CCK receptor antagonist, did not alter spontaneous food intake and did not reverse the suppression of feeding resulting from CCK-8. Bombesin (BBS 0.5–20 μg/kg]), thyrotropin releasing hormone (TRH 5–200 μg/kg]), and calcitonin (CC 2–22 μg/kg]) produced a dose-related suppression of food intake. BBS appeared to do so specifically. In contrast, TRH appeared to reduce feeding by temporarily debilitating the Ss and CC by evoking behavior (increased locomotor activity) incompatible with feeding. Intracerebroventricular (icv) injections of CCK-8, BBS, and CC produced dose-related inhibition of feeding, but only CCK-8 appeared to affect feeding behavior selectively. Reduced feeding after icv BBS was associated with excessive grooming, and icv CC, like systemic CC, increased locomotor behavior. (72 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) |
