| 米格列奈钙的合成工艺改进 |
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| 引用本文： | 刘文涛,郑德强,陈兆光,张玲. 米格列奈钙的合成工艺改进[J]. 食品与药品, 2009, 0(11) |
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| 作者姓名： | 刘文涛 郑德强 陈兆光 张玲 |
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| 作者单位： | 山东省生物药物研究院; |
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| 摘 要： | 目的改进米格列奈钙的合成工艺。方法以丁二酸二甲酯和苯甲醛为原料,经Stobble缩合、水解、拆分、还原、脱水,与顺-全氢异吲哚缩合后成盐等7步反应制得米格列奈钙。结果通过先建立目标手性中心,减少了昂贵中间体顺-全氢异吲哚的用量,降低了生产成本,总收率16.4%。结论此工艺操作简便,成本较低,适于工业化生产。
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| 关 键 词： | 米格列奈钙 药物制备 抗糖尿病药物 |
Improvement on Synthesis Process of Mitiglinide Calcium |
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| LIU Wen-tao,ZHENG De-qiang,CHEN Zhao-guang,ZHANG Ling. Improvement on Synthesis Process of Mitiglinide Calcium[J]. Food and Drug, 2009, 0(11) |
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| Authors: | LIU Wen-tao ZHENG De-qiang CHEN Zhao-guang ZHANG Ling |
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| Affiliation: | LIU Wen-tao,ZHENG De-qiang,CHEN Zhao-guang,ZHANG Ling (Institute of Biopharmaceuticals of Shandong Province,Jinan 250101,China) |
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| Abstract: | Objective To improve the synthesis process of.mitiglinide calcium.Methods Starting from dimethyl succinate and benzaldehyde,mitiglinide calcium was obtained via seven-step reactions including Stobble condensation,hydrolyzation,separation,reduction,anhydration,condensation with cis-hexahydroisoindoline and salt formation.Results The use amount of cis-hexahydroisoindoline was reduced through the construction of chiral center,so the cost of production of mitiglinide calcium could be decreased and the total yie... |
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| Keywords: | mitiglinide calcium drug preparation antidiabetic |
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