The Inflammatory Conspiracy in Multiple Sclerosis: A Crossroads of Clues and Insights through Mast Cells,Platelets, Inflammation,Gut Microbiota,Mood Disorders and Stem Cells |
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Authors: | Massimo Cocchi Elisabetta Mondo Marcello Romeo Giovanna Traina |
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Affiliation: | 1.Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell’Emilia, 40064 Bologna, Italy; (M.C.); (E.M.);2.Department of Biology and Biotechnology, University of Pavia, 27100 Pavia, Italy;3.Department of Pharmaceutical Sciences, University of Perugia, 06126 Perugia, Italy |
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Abstract: | Multiple Sclerosis is a chronic neurological disease characterized by demyelination and axonal loss. This pathology, still largely of unknown etiology, carries within it a complex series of etiopathogenetic components of which it is difficult to trace the origin. An inflammatory state is likely to be the basis of the pathology. Crucial elements of the inflammatory process are the interactions between platelets and mast cells as well as the bacterial component of the intestinal microbiota. In addition, the involvement of mast cells in autoimmune demyelinating diseases has been shown. The present work tries to hang up on that Ariadne’s thread which, in the molecular complexity of the interactions between mast cells, platelets, microbiota and inflammation, characterizes Multiple Sclerosis and attempts to bring the pathology back to the causal determinism of psychopathological phenomenology. Therefore, we consider the possibility that the original error of Multiple Sclerosis can be investigated in the genetic origin of the depressive pathology. |
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Keywords: | multiple sclerosis mast cells platelets inflammation gut microbiota mood disorders stem cells |
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