Effects of dietary oil related to the toxic oil syndrome on the lipids of guinea pig liver microsomes |
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Authors: | E de la Casa N Pérez-González C Sánchez-Bernal M Llanillo |
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Affiliation: | (1) Departamento de Bioquímica y Biología Molecular, Universidad de Salamanca, Edificio Departamental, Avda. Compo Charro s/n, 37007 Salamanca, Spain |
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Abstract: | The potential effects of oil specimens related to cases of toxic oil syndrome (TOS) on the liver microsomal lipid composition
from guinea pigs were investigated. For four weeks, animals were fed diets supplemented with either “case oil” (oil related
to cases of TOS) or “control oil” (oil unrelated to cases of TOS), either previously heated or not. Results were compared
with those from guinea pigs fed the same diet with no oil. The administration of case oil produced changes in liver microsomal
lipid composition. Statistically significant differences were also found between heated case and heated control oils. The
cholesterol/phospholipid molar ratios and the major phospholipid class distribution were unaffected under these diet conditions.
However, increases in the relative contents of linoleic and arachidonic acids and, simultaneously, a reduction in palmitic
and palmitoleic acid levels were observed by diet effects. Heated oil administration decreased the saturated/unsaturated ratios
in all cases. Our data suggest that changes observed in the fatty acid composition are attributable to the free fatty acid
contents of administered oils. The toxic constituents of case oil seem to be able to alter the liver microsomal lipid composition. |
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