| 4-（4-二甲氨基）苯基-6-甲基-5-乙氧羰基-3,4-二氢嘧啶-2-酮的合成 |
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| 引用本文： | 李公春,王志敏,彭秋瑾. 4-（4-二甲氨基）苯基-6-甲基-5-乙氧羰基-3,4-二氢嘧啶-2-酮的合成[J]. 河北化工, 2010, 33(7): 22-23 |
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| 作者姓名： | 李公春 王志敏 彭秋瑾 |
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| 作者单位： | 1. 许昌学院化学化工学院,河南,许昌,461000
2. 中南大学化学化工学院,湖南,长沙,410083 |
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| 摘 要： | 采用氨基磺酸作催化剂,无水乙醇作溶剂,对二甲氨基苯甲醛、乙酰乙酸乙酯和脲在加热搅拌条件下回流反应3 h,合成了4-（4-二甲氨基）苯基-6-甲基-5-乙氧羰基-3,4-二氢嘧啶-2-酮,产率为78.5%。
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| 关 键 词： | Biginelli反应 3,4-二氢嘧啶-2-酮 氨基磺酸 |
The Synthesis of 4-(4-Dimethylamino)Phenyl-6-Methyl-5-Ethoxycarbonyl-3,4-Dihydropyrimidin-2-One |
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| LI Gong-chun,WANG Zhi-min,PENG Qiu-jin. The Synthesis of 4-(4-Dimethylamino)Phenyl-6-Methyl-5-Ethoxycarbonyl-3,4-Dihydropyrimidin-2-One[J]. Hebei Chemical Engineering and Industry, 2010, 33(7): 22-23 |
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| Authors: | LI Gong-chun WANG Zhi-min PENG Qiu-jin |
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| Affiliation: | 1.College of Chemistry and Chemical Engineering,Xuchang University,Xuchang 461000,China;2.College of Chemistry and Chemical Engineering,Central South University,Changsha 410083,China) |
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| Abstract: | 4-（4-Dimethylamino）phenyl-6-methyl-5-ethoxycarbonyl-3,4-dihydropyrimidin-2-one was synthesized by 4-（dimethy-lamino）benzaldehyde,acetoacetate and urea,with catalyst of sulfamic acid,solvent of ethanol,refluxing for 3 h under the conditions of stirring,and the yield can reach 78.5%. |
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| Keywords: | Biginelli reaction 3 4-dihydropyrimidin-2-one sulfamic acid |
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