In vitro cytotoxicity of monodispersed hematite nanoparticles on Hek 293 cells

A simple hydrothermal method was developed to prepare monodispersed and well-crystallized hematite nanoparticles with a diameter distribution of about 180 nm. In-vitro cytotoxicity of such nanoparticles was carried out using Hek 293 cell culture system with different dosages. Assessment of cell viability reveals that hematite nanoparticles reduce cell viability in a dose- and time-dependent manner within a rather wide dosage range. Such cytotoxicity is correlative to the decrease of the activity of antioxidative enzymes induced by the oxidative stress in cells.