新型烟用香料2-(邻羟基苯基)环丙烷-1-甲酸的合成研究

以邻甲氧基苯乙烯为原料，先进行二氯加成反应，然后与丙二酸二乙酯进行环丙烷基化反应，再通过Krapcho 脱酯基反应，最后在碱性条件下用苯硫酚去甲基化形成新型烟用香料2-(邻羟基苯基)环丙烷-1-甲酸，总收率达53%。目标化合物通过核磁、质谱进行了表征。该路线反应条件温和、试剂廉价易得且收率高，为其工业化合成提供了参考。

Synthesis of Novel Tabacco Flavor 2-(2-Hydroxyphenyl)cyclopropane-1-carboxlic Acid

2-(2-Hydroxyphenyl)cyclopropane-1-carboxlic acid (HCCA) was prepared from the starting material of 2-methoxystyrene via the chlorine-addition, cyclopropanation reaction with diethyl malonate, Krapcho decarboxylation and demethylation using thiophenol as nucleophiles under alkali conditions with a high total yield of 53%. The target product was also confirmed through 1H NMR, 13C NMR, GC-MS and HRMS. The synthetic process of HCCA can be performed under mild reaction conditions with conveniently available reagents and good yields, providing a potential route for the large-scaled syntheses.