| 改性HA纳米粒子在骨组织工程中的应用[ ] |
| |
| 引用本文： | 杜婧羽,占晓,徐余欢,杨人元,张加奎,张道海.改性HA纳米粒子在骨组织工程中的应用[ ][J].精细化工,2024,41(3). |
| |
| 作者姓名： | 杜婧羽 占晓 徐余欢 杨人元 张加奎 张道海 |
| |
| 作者单位： | 贵州民族大学化学工程学院,贵州民族大学化学工程学院,贵州民族大学化学工程学院,贵州民族大学化学工程学院,贵州民族大学化学工程学院,贵州民族大学化学工程学院 |
| |
| 基金项目： | 国家自然科学(52163001)；贵州民族大学科研平台资助项目(GZMUGCZX[2021]01)；贵州省省级科技计划项目资助(黔科合平台人才-CXTD[2021]005,黔科合平台人才-GCC[2022]010-1)；贵州省省级科技计划项目资助(黔科合成果(2019)4022号)；贵阳市专家工作站(ZJGZZ2021-07)；贵阳市白云区科技计划项目(白科合同[2020]28号)。 |
| |
| 摘 要： | 羟基磷灰石(HA)具有优异的生物活性和生物相容性,广泛应用于骨修复、再生和置换等骨组织工程,但HA纳米粒子难分散、强度低、高分子相融性差等缺点限制了其应用。为了克服这些缺点,研究员致力于探索改性或复合HA的方法,以改善其分散性、亲水性、抗菌性以及机械强度等,来满足临床应用的要求。本篇综述总结归纳了当前主流的HA纳米粒子改性方法,包括离子掺杂、表面改性、材料复合等。最后,我们还讨论了当前HA复合材料的研究热点,以期为HA复合材料相关基础研究提供有益的借鉴与启示。
|
| 关 键 词： | 羟基磷灰石 骨组织工程 离子掺杂 表面改性 复合材料 |
| 收稿时间： | 2023/4/17 0:00:00 |
| 修稿时间： | 2023/7/30 0:00:00 |
The Application of Modified Hydroxyapatite Nanoparticles in Bone Tissue Engineering |
| |
| Du Jingyu,Zhan Xiao,Xu Yuhuan,Yang Renyuan,Zhang Jiakui and Zhang Daohai.The Application of Modified Hydroxyapatite Nanoparticles in Bone Tissue Engineering[J].Fine Chemicals,2024,41(3). |
| |
| Authors: | Du Jingyu Zhan Xiao Xu Yuhuan Yang Renyuan Zhang Jiakui and Zhang Daohai |
| |
| Affiliation: | School of Chemical Engineering of Guizhou Minzu University,Guizhou Guiyang? 550025,School of Chemical Engineering of Guizhou Minzu University,Guizhou Guiyang? 550025,School of Chemical Engineering of Guizhou Minzu University,Guizhou Guiyang? 550025,School of Chemical Engineering of Guizhou Minzu University,Guizhou Guiyang? 550025,School of Chemical Engineering of Guizhou Minzu University,Guizhou Guiyang? 550025,School of Chemical Engineering of Guizhou Minzu University,Guizhou Guiyang? 550025 |
| |
| Abstract: | Hydroxyapatite (HA) has excellent biological activity and biocompatibility, which widely used in bone repair, regeneration as well as replacement in bone tissue engineering. However, the intrinsic dispersibility, low mechanical properties, poor integration with polymer materials limit its application. In order to overcome their shortcomings, many researchers have explored the modify/composite methods of HA to improve the dispersion, hydrophilicity, antibacterial and mechanical strength for the clinical applications. This review introduces commonly modification methods of HA nanoparticles, such as ions doping, surface modification and material composite. Finally, we also discuss the current research hotspots so that provide more enlightenment and instructive effect on fundamental research of HA composite materials. |
| |
| Keywords: | Hydroxyapatite Bone tissue engineering ions doping Surface modification composite materials |
|
| 点击此处可从《精细化工》浏览原始摘要信息 |
|
点击此处可从《精细化工》下载全文 |
|
