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| Inhibitory activity of gold and silica nanospheres to vascular endothelial growth factor （VEGF）-mediated angiogenesis is determined by their sizes | |
| 作者姓名： | Dong Hyun Jo ;Jin Hyoung Kim ;Jin Gyeong Son ;Yuanze Piao ;Tae Geol Lee ;Jeong Hun Kim |
| 作者单位： | [1]Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University, Seoul, 110-744, Republic of Korea; [2]Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 110-799, Republic of Korea; [3]Center for Nano-Bio Convergence, World Class Laboratory, Korea Research Institute of Standards and Science, Daejeon, 305-340, Republic of Korea; [4]Department of Chemistry and KI for the NanoCentury, KAIST, Daejeon, 305-701, Republic of Korea; [5]Graduate School of Convergence Science and Technology, Seoul National University, Seoul 151-742 & Advanced Institutes of Convergence Technology, Suwon 443-270, Republic of Korea; [6]Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, 110-744, Republic of Korea |
| 基金项目： | Acknowledgements This work was supported by the Bio-Signal Analysis Technology Innovation Program （2009-0090895） of MEST/NRF, the Pioneer Research Program （2012- 0009544） of MEST/NRF, the Seoul National University Research Grant （800-20130338）, the Seoul National University Hospital Research Fund （03-2013-0070）, and the Development of Characterization Techniques for the Nano-materials Safety Project of Korea Research Council of Fundamental Science ＆ Technology （KRCF）. |
| 摘 要： | Nanoparticles can be involved in biological activities such as apoptosis, angiogenesis, and oxidative stress by themselves. In particular, inorganic nanoparticles such as gold and silica nanoparticles are known to inhibit vascular endothelial growth factor （VEGF）-mediated pathological angiogenesis. In this study, we show that anti-angiogenic effect of inorganic nanospheres is determined by their sizes. We demonstrate that 20 nm size gold and silica nanospheres suppress VEGF-induced activation of VEGF receptor-2, in vitro angiogenesis, and in vivo pathological angiogenesis more efficiently than their 100 nm size counterparts. Our results suggest that modulation of the size of gold and silica nanospheres determines their inhibitory activity to VEGF-mediated angiogenesis. |
| 关 键 词： | 血管内皮生长因子受体 二氧化硅纳米粒子 抗血管生成 VEGF 抑制活性 纳米球 黄金 介导 |
Inhibitory activity of gold and silica nanospheres to vascular endothelial growth factor (VEGF)-mediated angiogenesis is determined by their sizes |
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| Dong Hyun Jo,;Jin Hyoung Kim,;Jin Gyeong Son,;Yuanze Piao,;Tae Geol Lee,;Jeong Hun Kim.Inhibitory activity of gold and silica nanospheres to vascular endothelial growth factor (VEGF)-mediated angiogenesis is determined by their sizes[J].Nano Research,2014,7(6):844-852. | |
| Authors: | Dong Hyun Jo Jin Hyoung Kim Jin Gyeong Son Yuanze Piao Tae Geol Lee Jeong Hun Kim |
| Affiliation: | 1. Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University, Seoul, 110-744, Republic of Korea 2. Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 110-799, Republic of Korea 3. Center for Nano-Bio Convergence, World Class Laboratory, Korea Research Institute of Standards and Science, Daejeon, 305-340, Republic of Korea 4. Department of Chemistry and KI for the NanoCentury, KAIST, Daejeon, 305-701, Republic of Korea 5. Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 151-742, Korea 7. Advanced Institutes of Convergence Technology, Suwon, 443-270, Republic of Korea 6. Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, 110-744, Republic of Korea |
| Abstract: | Nanoparticles can be involved in biological activities such as apoptosis, angiogenesis, and oxidative stress by themselves. In particular, inorganic nanoparticles such as gold and silica nanoparticles are known to inhibit vascular endothelial growth factor (VEGF)-mediated pathological angiogenesis. In this study, we show that anti-angiogenic effect of inorganic nanospheres is determined by their sizes. We demonstrate that 20 nm size gold and silica nanospheres suppress VEGF-induced activation of VEGF receptor-2, in vitro angiogenesis, and in vivo pathological angiogenesis more efficiently than their 100 nm size counterparts. Our results suggest that modulation of the size of gold and silica nanospheres determines their inhibitory activity to VEGF-mediated angiogenesis. |
| Keywords: | nanospheres anti-angiogenesis effects inorganic nanoparticles vascular endothelialgrowth factor pathological angiogenesis |
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