高速剪切—反相细乳液法制备负载氯沙坦淀粉纳米粒

目的:探究高速剪切—反相细乳液交联法制备负载氯沙坦淀粉纳米粒的可行性。方法:以氯沙坦为模型药物、三偏磷酸钠为交联剂，考察淀粉溶液浓度、三偏磷酸钠添加量、交联时间和剪切速率对淀粉纳米粒粒径和产率的影响规律，并采用光学显微摄像仪、红外光谱仪、X射线衍射仪对负载氯沙坦淀粉纳米粒进行表征。结果:纳米粒制备的最佳工艺为淀粉溶液浓度15%,三偏磷酸钠添加量25%,交联时间3 h,剪切速率5 000 r/min,该条件下制得的纳米粒粒度最小为755.2 nm,产率可达69.5%;光学显微摄像显示纳米粒形态圆整，颗粒饱满且均为球形；FTIR显示氯沙坦成功负载于淀粉纳米粒中；XRD显示纳米粒以无定形结构存在。结论:高速剪切耦合反相细乳液交联法可以制备出小粒径的载药淀粉纳米粒。

Preparation of losartan loaded starch nanoparticles by high-speed shear-inverse miniemulsion method

Objective: This study aimed to explore the feasibility of preparation of loaded losartan starch nanoparticles by high-speed shear-reverse microemulsion crosslinking. Methods: Using losartan as model drug and sodium trimetaphosphate as crosslinking agent, the effects of starch solution concentration, sodium trimetaphosphate addition amount, crosslinking time and shear rate on particle size and yield of starch nanoparticles were investigated. Optical micrography, infrared spectrometer and X-ray diffraction were used to characterize losartan loaded starch nanoparticles. Results: The optimal preparation process of nanoparticles was 15% starch solution concentration, 25% sodium trimetaphosphate, 3 h crosslinking time, 5 000 r/min shear rate. Under the control of these conditions, the minimum size of nanoparticles was 755.2 nm, and the yield reached 69.5%. Optical micrography showed that the nanoparticles were round, full and spherical. FTIR showed that losartan was successfully loaded into starch nanoparticles. XRD showed that the nanoparticles exist in amorphous structure. Conclusion: Small particle size drug-carrying starch nanoparticles can be prepared by high-speed shear coupled reversed-phase fine emulsion crosslinking method.