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| 水飞蓟宾的负离子电喷雾离子阱质谱研究 | |
| 引用本文： | 韩建平,李伟,张超,王宏志,高钧,刘昌孝. 水飞蓟宾的负离子电喷雾离子阱质谱研究[J]. 质谱学报, 2009, 30(1): 6-11 |
| 作者姓名： | 韩建平 李伟 张超 王宏志 高钧 刘昌孝 |
| 作者单位： | 1．天津天士力集团有限公司，天津 300402； 2．天津大学化工学院，天津 300072； 3．天津药物研究院，天津药代动力学与药效动力学省部共建国家重点实验室，天津 300193 |
| 摘 要： | 采用电喷雾离子阱（ESI-MS）质谱技术对水飞蓟宾的结构和裂解途径进行研究。采用ESI-MS获得了 m/z 481[M-H]-，采用ESI-MS2获得了 m/z 453、m/z 301等碎片离子。发现ESI-MS2质谱生成A环和B环C—O—C键断裂的碎片，并对 m/z 453、m/z 301特征碎片离子进行ESI-MS3质谱研究，归属了其主要特征碎片离子，分析和讨论了该化合物的结构和质谱特征。 |
| 关 键 词： | 水飞蓟宾 电喷雾离子阱质谱 裂解途径 |
| 收稿时间： | 2008-04-29 |
Study on Silybin in Negative Mode by Ion Trap Mass Spectrometry |
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| HAN Jian-ping,LI Wei,ZHANG Chao,WANG Hong-zhi,GAO Jun,LIU Chang-xiao. Study on Silybin in Negative Mode by Ion Trap Mass Spectrometry[J]. Journal of Chinese Mass Spectrometry Society, 2009, 30(1): 6-11 | |
| Authors: | HAN Jian-ping LI Wei ZHANG Chao WANG Hong-zhi GAO Jun LIU Chang-xiao |
| Affiliation: | 1．Tasly R&D Institute，Tianjin Tasly Group Co．Ltd．，Tianjin 300402， China； 2．School of Chemical Engineering and Technology，Tianjin University，Tianjin 300072, China； 3．Tianjin State Key Laboratory of Pharmacokinetics and Pharmacodynamics，Tianjin institute of Pharmaceutical Research，Tianjin 300193, China |
| Abstract: | The structure and fragmentation pathway of silybin were elucidated by electron spray ionization mass spectrometry (ESI-MS）．Quasi-molecular ion peak m/z 481 [M-H]- was detected by ESI-MS， and the ions of m/z 453 and m/z 301 were detected by ESI-MS2．The fragment routes of characteristic were discussed on the basis of ESI mass spectra．The full scan MS2 spectra of silybin gave characteristic fragment ions formed through cleavage of the C—O—C bond at A-ring and B-ring. The full scan MS3 spectra of fragment m/z 453, m/z 301 was obtained by ion trap mass spectrometry．The characteristic fragmentation was used to prove the structure of m/z 453, m/z 301． |
| Keywords: | silybin electronsprayionization-iontrapmassspectrometry fragmentationpathway |
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