TOXICITY, MUTAGENICITY AND TERATOGENICITY OF BREVIANAMIDE, VIOMELLEIN AND XANTHOMEGNIN; SECONDARY METABOLITES OF PENICILLIUM VIRIDICATUM |
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| Authors: | ANTHONY J. DELUCCA JOHN J. DUNN LOUISE S. LEE ALEX CIEGLER |
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| Affiliation: | Southern Regional Research Center Science and Education Administration U.S. Department of Agriculture New Orleans, LA 70179 |
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| Abstract: | The three major secondary metabolites of Penicillium viridicatum, brevianamide, xanthomegnin, and viomellein were tested for mutagenicity by the Salmonella/microsome test and for toxicity and teratogenicity by the chick embryo test. None were mutagenic. Viomellein was mildly toxic and teratogenic, xanthomegnin was the most toxic and was not a teratogen, and brevianamide was not toxic yet was the most teratogenic. |
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