| 叶绿素、血卟啉致动脉粥样硬化斑块光敏化作用对比研究 |
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| 引用本文： | 邓永华,余枢,汪道文,李正佳,刘安平.叶绿素、血卟啉致动脉粥样硬化斑块光敏化作用对比研究[J].应用激光,1992(2). |
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| 作者姓名： | 邓永华 余枢 汪道文 李正佳 刘安平 |
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| 作者单位： | 同济医科大学同济医院，同济医科大学同济医院，同济医科大学同济医院，华中理工大学光学研究所，华中理工大学光学研究所 430030 研究生 湖南医科大学附二医院内科，430030 导师，430030 |
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| 摘 要： | 以荧光显微镜观察经生理盐水、叶绿素、血叶啉处理人尸粥样斑块及正常血管,发现叶绿素、血卟啉能选择性聚积于动脉粥样硬化斑块。以等量的Nd:YAG倍频激光能量照射,叶绿素、血卟啉处理组斑块激光消融涤度大于对照组斑块消融深度,P<0.01;提示叶绿素、血卟啉是Nd:YAG倍频激光血管成形术的理想光敏剂。
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| 关 键 词： | 叶绿素 血卟啉 斑块 光敏化 消融 荧光 |
Comparative Study of Photodynamic Therapy with Chlorophyll and Hematoporphyrin Derivatives in Laser Ahlation of Atherosclerotic Plaques |
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| Deng Yonghua,Yu Shu,Wang Daowen,Li Zhengjia,Liu Anping.Comparative Study of Photodynamic Therapy with Chlorophyll and Hematoporphyrin Derivatives in Laser Ahlation of Atherosclerotic Plaques[J].Applied Laser,1992(2). |
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| Authors: | Deng Yonghua Yu Shu Wang Daowen Li Zhengjia Liu Anping |
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| Affiliation: | Deng Yonghua,Yu Shu,Wang Daowen,Li Zhengjia,Liu Anping Department of Cardiology,Tongji Hospital,Tongji Medical Umiversity,Wuhan,Hubei Laser Institute,Hua Zhong Science and Technology University,Wuhan,Hubei |
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| Abstract: | Selective concentration within atherosclerotic plaques by chlorophyll and hematopor-phyrin derivatives were varifred with ultraviolet microscope in vitro. Postmortem human aortaswere exposed to equal total energy of double frequency Nd:YAG laser irradiation, there weremore extensive ablation in plaques treated with chlorophyll and hematoporphyrin derivatives com-pared with plaques treated with normal saline, P<0.01. Results indicated that chlorophyll andhematoporphyrin derivatives may be ideal photo-sensitizers for double frequency Nd:YAG laserangioplasty. |
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| Keywords: | chlorophyll hematoporphyrin derivatives atherosclerotic plaques laser ablation photodynamic therapy fluorescence |
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