| 离子液体催化香豆素-3-羧酸的合成研究 |
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| 引用本文： | 王潇,韩相恩. 离子液体催化香豆素-3-羧酸的合成研究[J]. 化工科技, 2011, 19(6): 34-36,53 |
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| 作者姓名： | 王潇 韩相恩 |
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| 作者单位： | 中国矿业大学化工学院,江苏徐州,221008 |
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| 基金项目： | 中国矿业大学大型仪器设备开放共享基金 |
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| 摘 要： | 在乙醇中,以[Bmim]BF4为催化剂,通过水杨醛与米氏酸的Knoevenagel缩合反应合成了香豆素-3-羧酸,对影响香豆素-3-羧酸产率的各反应条件进行了研究,得出最佳工艺条件为n(米氏酸):n(水杨醛)=1.2:1.0,[Brnim]BF4 0.4mL,乙醇15 mL(均对2.4g水杨醛),反应时间1.5h,香豆...
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| 关 键 词： | 香豆素-3-羧酸 合成 离子液体 Knoevenagel缩合 |
Studies on catalysis and synthesis of coumarin-3-carboxylic acid in ionic liquid |
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| WANG Xiao,HAN Xiang-en. Studies on catalysis and synthesis of coumarin-3-carboxylic acid in ionic liquid[J]. Science & Technology In Chemical Industry, 2011, 19(6): 34-36,53 |
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| Authors: | WANG Xiao HAN Xiang-en |
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| Affiliation: | (School of Chemical Engineering and Technology,China University of Mining and Technology,Xuzhou 221008,China) |
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| Abstract: | Coumarin-3-carboxylic acid was synthesized from salicylaldehyde and Meldrum′s acid in ethanol by Knoevenagel condensation reaction using BF4 as the catalyst.The effects of reaction condition were investigated.The optimum reaction conditions were obtained as follows：salicylaldehyde=2.4 g,Meldrum′s acid =3.46 g,BF4=0.4 mL,ethanol =15 mL and reaction time=1.5 h.The yield of coumarin-3-carboxylic acid reached higher than 95%. |
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| Keywords: | Coumarin-3-carboxylic acid Synthesis Ionic liquid Knoevenagel condensation reaction |
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