| 质子泵抑制剂兰索拉唑的合成 |
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| 引用本文： | 郭罕奇,单尚.质子泵抑制剂兰索拉唑的合成[J].化工生产与技术,2011,18(6):6-7,30,3. |
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| 作者姓名： | 郭罕奇 单尚 |
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| 作者单位： | 浙江工业大学化学工程与材料学院,杭州,310014 |
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| 摘 要： | 以2,3-二甲基-4-硝基吡啶-N-氧化物为原料,通过2个“一锅法”,经4步反应合成兰索拉唑.改进的合成路线缩短了合成工艺流程提高了产品收率,反应条件相对温和.总收率达到39.2％,高于文献报道的18.8％,适合工业化生产.
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| 关 键 词： | 兰索拉唑 2 3-二甲基-4-硝基吡啶-N-氧化物 2 2 2-三氟乙醇 合成 |
Synthesis of the Proton Pump Inhibitor Lansoprazole |
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| Guo Hanqi,Shan shang.Synthesis of the Proton Pump Inhibitor Lansoprazole[J].Chemical Production and Technology,2011,18(6):6-7,30,3. |
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| Authors: | Guo Hanqi Shan shang |
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| Affiliation: | (College of Chemical Engineering and Materials,Zhejiang University of Technology,Hangzhou 310014) |
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| Abstract: | The proton pump inhibitor,2-3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl methyl]sulfinyl-1H-benzimidazole was synthesized via 4 steps of reactions from the starting material 2,3-dimethyl-4-nitropyridine-N-oxide.The improved synthetic route increased the product yield and the reaction conditions mild relatively.The total yield was up to 39.2% exceeding literature value 18.8% |
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| Keywords: | lansoprzole 2 3-dimethyl-4-nitropyridine-N-oxide 2 2 2-trifluorethanol synthesis |
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