| 1-[(4-苄氧基苯基)-2-[2-(4-甲氧基苯基)]乙胺基]乙醇的合成 |
| |
| 引用本文： | 陈旭冰,李龙星,陈光勇,刘光明,邓杰.1-[(4-苄氧基苯基)-2-[2-(4-甲氧基苯基)]乙胺基]乙醇的合成[J].化工科技,2011,19(6):23-25. |
| |
| 作者姓名： | 陈旭冰 李龙星 陈光勇 刘光明 邓杰 |
| |
| 作者单位： | 1. 大理学院药学院,云南大理,671000
2. 重庆医药工业研究院,重庆,400061 |
| |
| 基金项目： | 云南省教育厅科学研究基金资助项目 |
| |
| 摘 要： | 以对-羟基苯乙酮为原料,经溴代后,与对甲氧基苯乙胺缩合,再经硼氢化钠还原,得到目标化合物.目标化合物的结构通过IR、1H-NMR(CDC13)及MS确证,有望得到高活性及高选择性的β3-肾上腺素受体激动剂.
|
| 关 键 词： | 对-羟基苯乙酮 溴代 对甲氧基苯乙胺 β3-肾上腺素受体激动剂 |
The synthesis of 1-[(4-benzyloxyphenyl)-2-[2-(4-methoxylphenyl)]ethylamino]ethanol |
| |
| CHEN Xu-bing,LI Long-xing,CHEN Guang-yong,LIU Guang-ming,DENG Jie.The synthesis of 1-[(4-benzyloxyphenyl)-2-[2-(4-methoxylphenyl)]ethylamino]ethanol[J].Science & Technology In Chemical Industry,2011,19(6):23-25. |
| |
| Authors: | CHEN Xu-bing LI Long-xing CHEN Guang-yong LIU Guang-ming DENG Jie |
| |
| Affiliation: | 1.Faculty of Pharmacy of Dali University,Dali 671000,China;2.Chongqing Pharmaceutical Research Institute,Chongqing 400061,China) |
| |
| Abstract: | Starting from 4-hydroxy acetophenone,the target compounds was synthesized in three steps,including brominating,amination with（4-methoxyphenyl）ethylamine and reduction by borohydride sodium.Structure of the target compounds was confirmed by IR,1H-NMR（CDCl3）and MS.Such studies may be useful in proposing new compounds with enhanced activity and selectivity profile for β3-adrenoceptors. |
| |
| Keywords: | 4-Hydroxy acetophenone Brominating （4-Methoxyphenyl）ethylamine Beta-3 adrenergic receptor agonists |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
