Bioactive superparamagnetic nanoparticles for multifunctional composite bone cements |
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| Affiliation: | 1. Institute of Materials Physics and Engineering, Department of Applied Science and Technology, Politecnico di Torino, C.so Duca degli Abruzzi 24, 10129 Torino, Italy;2. Department of Orthopedic Surgery, Brigham & Women''s Hospital, Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA;1. Department of Metallurgical Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India;2. Vignan’s Institute of Information Technology, Visakhapatnam, 530049, India;3. Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai, 400085, India;4. Technical Physics Division, Bhabha Atomic Research Centre, Mumbai, 400085, India;1. College of Medical Technology and Engineering, Henan University of Science and Technology, Luo Yang 471023, Henan, PR China;2. School of Chemical Engineering and Pharmacy of Henan University of Science and Technology, Luo Yang 471023, Henan, PR China;3. College of Material Science and Engineering, Henan University of Science and Technology, Luo Yang 471023, Henan, PR China;4. Medical College, Henan University of Science and Technology, Luoyang 471023, Henan, PR China;5. Henan Medical Instrument Testing Institute, Zhengzhou 450000, Henan, PR China;1. Department of Physics, Lahore College for Women University, Lahore, Pakistan;2. Department of Materials Science & Metallurgy, University of Cambridge, CB3 0FS, Cambridge, UK |
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| Abstract: | Magnetite-based nanoparticles (NPs) were synthesized by co-precipitation process and coated with a thin layer of silica, eventually doped with calcium, by a modified Stöber method. The potential bioactive behavior of NPs was investigated by dipping samples in simulated body fluid (SBF) and analyzing them with Field-Emission Scanning Electron Microscope (FESEM) equipped with Energy Dispersive Spectroscopy (EDS). Silica-coated NPs displayed evidence of HAp grown on their surface and were then used as a filler for polymethyl methacrylate (PMMA)-based bone cement to impart bioactive and magnetic properties. The influence of the amount of magnetic NPs and the cement mixing method (manual or mechanical) were estimated in terms of NPs dispersion, compressive strength and bioactive behavior. The obtained data evidenced that both the NPs amount and the mixing method influenced the strength of the composites. A delay in the bioactivity was observed for manual mixed cement; moreover, mechanically mixed composites containing a low amount of NPs showed superparamagnetic behavior. These results suggest that the investigated composite bone cements are promising materials for the treatment of bone tumors and associated complications. |
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| Keywords: | Superparamagnetic nanoparticles Bioactive nanoparticles Composite bone cement Tumor treatment |
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