Development of multifunctional cobalt ferrite/hydroxyapatite nanocomposites by microwave assisted wet precipitation method: A promising platform for synergistic chemo-hyperthermia therapy |
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| Affiliation: | 1. Department of Physics, National Institute of Technology, Tiruchirappalli, India;2. Department of Physics, Periyar University, Salem, India;1. King Abdullah Institute for Nanotechnology, King Saud University, Riyadh, Saudi Arabia;2. Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia;3. Nanomedicine Research Unit, Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia;1. Department of Physics, Periyar University, Salem 636011, India;2. Department of Physics, KSR K. S. Rangasamy College of Arts and Science (Autonomous), Tiruchengode 637 215, India;3. Department of Oral and Maxillofacial Surgery, Sibar Institute of Dental Sciences, Guntur 522 022, Andhra Pradesh, India;1. Department of Physics, Indraraj Arts, Commerce and Science College, Sillod, Aurangabad, India;2. Department of Physics, Deogiri College, Aurangabad, 431001, Maharashtra, India;3. Department of Physics, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431004, Maharashtra, India |
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| Abstract: | Functional nanocomposites capable of multimodal therapy hold great potential to improve the efficiency of cancer therapy. Herein, we report a magnetic nanocomposite of cobalt ferrite/hydroxyapatite followed by loading a chemotherapeutic drug (5-fluorouracil, FU) to construct the intelligent drug delivery system and/or hyperthermia carrier. To do that, cobalt ferrite/hydroxyapatite nanocomposite was successfully synthesized by microwave assisted wet precipitation method, subsequently, FU loaded onto the formed composites through adsorption method. This nanocomposite exhibits ferromagnetic behaviour with a magnetic saturation value of approximately 2.5–8.2 emu/g. Upon alternating magnetic field, it could generate hyperthermia temperature within a short time (43°C in 4.5 min) and facilitate the release of encapsulated FU from the composite with enhanced release rate. These multifunctional carriers also demonstrate a noticeable proliferative activity against healthy fibroblast cells (L929) and suppressed growth against osteosarcoma cells (MG63). Therefore, this studied nanoplatform might be a promising candidate for synergistic chemo-hyperthermia therapy. |
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| Keywords: | Cobalt ferrite Hydroxyapatite Chemotherapy Hyperthermia |
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