Hydroxyapatite/gelatin/gellan sponges as nanocomposite scaffolds for bone reconstruction |
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Authors: | Niccoletta Barbani Giulio D Guerra Caterina Cristallini Patrizia Urciuoli Riccardo Avvisati Alessandro Sala Elisabetta Rosellini |
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Affiliation: | (1) Department of Chemical Engineering, Industrial Chemistry and Materials Science, University of Pisa, Largo Lucio Lazzarino, 56122 Pisa, Italy;(2) Institute for Composite and Biomedical Materials, C.N.R., U.O.S. of Pisa, Largo Lucio Lazzarino, 56122 Pisa, Italy;(3) Cell Biology and Tissue Regeneration Laboratory, Immunohematology 2 Unit, Azienda Ospedaliera Universitaria Pisana, Via Paradisa 1, 56124 Pisa, Italy |
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Abstract: | The aim of this work was the morphological, physicochemical, mechanical and biological characterization of a new composite
system, based on gelatin, gellan and hydroxyapatite, and mimicking the composition of natural bone. Porous scaffolds were
prepared by freeze–drying technique, under three different conditions of freezing. The morphological analysis showed a homogeneous
porosity, with well interconnected pores, for the sample which underwent a more rapid freezing. The elastic modulus of the
same sample was close to that of the natural bone. The presence of interactions among the components was demonstrated through
the physicochemical investigation. In addition, the infrared chemical imaging analysis pointed out the similarity among the
composite scaffold and the natural bone, in terms of chemical composition, homogeneity, molecular interactions and structural
conformation. Preliminary biological characterization showed a good adhesion and proliferation of human mesenchymal stem cells. |
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