Synthesis of [(2'S, 3'S)-bis(hydroxylmethyl)pyrrolidin-1-yl] purine and pyrimidine nucleosides as potential antiviral agents |
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| Authors: | T Oohashi S Nishiyama S Yamamura K Kato |
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| Affiliation: | Department of Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan. |
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| Abstract: | ![]()
The enantiomerically pure synthesis of [(2'S, 3'S)-bis(hydroxymethyl)pyrrolidin-1-yl] thymine 17 and -adenine 20 was achieved via construction of the base on the 1-amino-pyrrolidine 15, and their anti-HSV-1 and -2, and anti-HIV-1 activities were evaluated. |
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