Neutron reflectometry of supported hybrid bilayers with inserted peptide |
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Authors: | Smith Matthew B McGillivray Duncan J Genzer Jan Lösche Mathias Kilpatrick Peter K |
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Affiliation: | Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, USA. |
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Abstract: | The insertion of a synthetic amphiphilic, α-helical peptide into a supported hybrid bilayer membrane (HBM) was studied by neutron reflectometry to elucidate the resulting nanostructure. The HBM consisted of a self-assembled monolayer of perdeuterated octadecanethiol on gold and an overlying leaflet of acyl-deuterated phosphatidylcholine (d-DMPC). Using contrast variation, several reflectivity spectra were recorded for each step of film fabrication, and simultaneously modeled. This analysis indicated that peptide insertion into the DMPC lipid leaflet is the likeliest mode of incorporation. |
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