特异性鸡蛋黄抗体的毒理学安全性研究

评价特异性鸡蛋黄抗体作为保健食品素材的食用安全性。采用急性毒性试验、小鼠骨髓微核试验、小鼠精子畸形试验、Ames试验和30d喂养试验进行检测。结果表明:雌、雄小鼠急性经口LD50>20ml/kg体重,属无毒级;小鼠骨髓微核试验、精子畸形试验和Ames试验结果均为阴性;30d喂养试验未显示明显毒性。

Toxicological Assessment on Prepared IgY Safety

To evaluate the edible safety of prepared IgY. Some tests of acute oral toxicity, bom marrow cell micronucleus, sperm shape abnormality in mice, Ames and thirty - day feeding were conducted in our study.The LDs0 of all the rats and mice were more than 20ml/kg bw, so the teeth protection spray belonged to actually non - toxicity; tests of born marrow cell micronucleus, sperm shape abnormality in mice, Ames were negative; The thirty - day feeding test in rats demonstrated that it had no distinctive effects on routine blood, body weight and biochemical index. The teeth protection spray was safe for edibility.