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制备L-亮氨酸螯合钙的新工艺及其生物利用度的研究
引用本文:甘林火,翁连进,刘青,邓爱华.制备L-亮氨酸螯合钙的新工艺及其生物利用度的研究[J].食品与发酵工业,2008,34(3):53-57.
作者姓名:甘林火  翁连进  刘青  邓爱华
作者单位:华侨大学化工与制药工程系,福建泉州,362021
基金项目:福建省科技计划 , 福建省泉州市科技计划
摘    要:采用单因子静态实验,考察了温度、NaOH和亮氨酸的摩尔比、L-亮氨酸浓度、树脂量对利用离子交换法制备L-亮氨酸螯合钙新工艺的影响,并测定了25℃下的离子交换动力学曲线。结果表明:交换可在室温下进行;NaOH与亮氨酸适宜的摩尔比1:1~1.3:1;L-亮氨酸浓度应控制在0.3 mol/L以下;适宜的树脂用量应满足树脂中钙与溶液中亮氨酸的摩尔比1:2;交换平衡时间为15 min。根据最佳工艺条件设计制备L-亮氨酸螯合钙的新工艺流程。采用小鼠对L-亮氨酸螯合钙和葡萄糖酸钙进行药动学和药效学实验对比,结果表明:L-亮氨酸钙的生物利用度比葡萄糖酸钙要高,其相对生物利用度是葡萄糖酸钙的175.3%,并具有缓释、药效时间长、不需要消耗胃酸等特点;L-亮氨酸螯合钙能显著性增加大鼠股骨重量,饲料中添加兼有促进小鼠体重增长的作用。

关 键 词:L-亮氨酸螯合钙  离子交换  生物利用度
修稿时间:2007年11月23

The New Technology of Preparation and the Study Of Bio-availability of the Complex of L-leucine Calcium
Gan Linhuo,Weng Lianjin,Liu Qing,Deng Aihua.The New Technology of Preparation and the Study Of Bio-availability of the Complex of L-leucine Calcium[J].Food and Fermentation Industries,2008,34(3):53-57.
Authors:Gan Linhuo  Weng Lianjin  Liu Qing  Deng Aihua
Abstract:Through the experiments of single factor,the effects of temperature,the ratio of NaOH to Leucine,the concentration of Leucine,the quantity of resin on exchange ratio were determined,its exchange kinetic curve at 25℃was also measured.The results showed that exchange could be operated at room tem- perature,the proper mol ratio was between 1:1 and 1.3:1,the concentration of Leucine under 0.3 mol/L, the ratio of calcium in resin and Leucine in soltion was 1:2 during exchange,the equilibrium time was 15 minutes.Based on these conditions,the new technology of preparation of the complex of L-leucine Calcium was designed.The experimental comparisons of pharmacokinetics and pharmacodynamics between the com- plex of L-leucine calcium and glucose calcium were performed on the rats.The results showed that relative bio-availability of leucine calcium group to glucose calcium group was 175.3%,relative bio-availability of L- leucine calcium compound was higher than glucose calcium,and the complex of L-leucine calcium also had characteristics of being relaxed dosage and no consume of stomach acid,etc.The weight of rat was signifi- cantly increased in the calcium leucine compound group.Absorption effect of the complex of L-leucine calci- um was better than glucose calcium at the same dosage.
Keywords:calcium chelate L-leucine  ion exchange  bio-availability
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