Intracerebroventricular Self-Administration of Commonly Abused Anabolic-Androgenic Steroids in Male Hamsters (Mesocricetus auratus): Nandrolone, Drostanolone, Oxymetholone, and Stanozolol.

Previous studies by the authors have shown voluntary intracerebroventricular (icv) testosterone self-administration in hamsters (Mesocricetus auratus). Here, the authors compared icv self-administration of 4 anabolic steroids (drostanolone, nandrolone, oxymetholone, and stanozolol) at 0.1, 1.0, and 2.0 μg/μl, each for 8 days. Males (n=8/group) showed the highest levels of operant behavior for injectable steroids (drostanolone, nandrolone) compared with orally active androgens (oxymetholone, stanozolol). For nandrolone, responses on the active and inactive nose-pokes averaged 22.3 ± 4.6/4 hr and 10.7 ± 2.0/4 hr, respectively. Responding for drostanolone was similar. Males self-administering oxymetholone or stanozolol did not prefer the active nose-poke. These data demonstrate that injectable androgens are more reinforcing than oral steroids. (PsycINFO Database Record (c) 2010 APA, all rights reserved)