Effect of age and dietary fat (fish,corn and coconut oils) on tocopherol status of C57BL/6Nia mice |
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Authors: | Simin Nikbin Meydani Alice C Shapiro Mohsen Meydani John B Macauley Jeffrey B Blumberg |
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Affiliation: | (1) USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St., O2111 Boston, MA |
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Abstract: | The effect of age and dietary fat type on tocopherol status was investigated using young and old C57BL/6Nia mice fed semipurified
diets containing 5% (by weight) fish, corn or coconut oils and supplemented with 30, 100 or 500 ppm dl-α-tocopheryl acetate
for 6 wk. Tocopherol levels in the diets, plasma, liver, kidney and lung were measured by high performance liquid chromatography
following appropriate extractions. The results indicate that mice fed fish oil maintain lower plasma and tissue tocopherol
concentrations than those fed corn and cononut oils (fish<corn oil<coconut oil). The difference was not due to a loss of tocopherol
prior to consumption, but rather appeared to occur during the absorption process. Old mice had lower plasma and liver tocopherol
concentrations than young mice. Old mice fed fish oil, however, maintained plasma tocopherol levels better than young mice
fed fish oil, presumably due to their larger tocopherol pool. No age effect was detected on kidney and lung tocopherol levels.
It is concluded that tocopherol status is affected by age and dietary fat type, especially fish oil. |
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