Synthesis and characterization of perovskite type of La1-xBaxMnO3 nanoparticles with investigation of biological activity |
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| Affiliation: | 1. Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Mersin University, Turkey, 33343 Mersin, Turkey;2. Food Processing Programme, Technical Science Vocational School, Mersin University, 33343 Mersin, Turkey;3. Department of Physics, Science Faculty, Bursa Uludag University, 16100 Bursa, Turkey;4. Department of Biomedical Engineering, Pamukkale University, 20160 Denizli, Turkey;5. Faculty of Engineering, Department of Engineering Fundamental Sciences, Tarsus University, 33400 Tarsus, Turkey;6. Department of Environmental Engineering, Mersin University, 33343 Mersin, Turkey |
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| Abstract: | The enhanced biological activity of perovskite type La1-xBaxMnO3 (x = 0.2, 0.3, 0.4) nanoparticle was studied based on antioxidant, antimicrobial, anti-biofilm, bacterial viability inhibition, and DNA cleavage studies. The nanoparticles were prepared by Sol-gel technique and they were analyzed on structure and morphological by XRD and SEM. La0.6Ba0.4MnO3 showed the highest DPPH free radical scavenging activity and iron chelating activity as 67.23% and 46.54%, respectively. All tested lanthanum nanoparticles showed good chemical nuclease activity. C. tropicalis was the most affected species by lanthanum nanoparticles and MIC values were 4 µg/mL, 8 µg/mL, and 16 µg/mL for La0.7Ba0.4MnO3, La0.6Ba0.4MnO3, and La0.8Ba0.2MnO3, respectively. La0.7Ba0.4MnO3 exhibited the highest percentage of biofilm inhibition against P. aeruginosa and S. aureus as 99.78% and 98.38%, respectively. Cell viability assay demonstrated that La0.7Ba0.4MnO3, La0.6Ba0.4MnO3, and La0.8Ba0.2MnO3 showed %100 cell viability inhibition after 30 and 60 min treatment. |
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| Keywords: | Lanthanum nanoparticles Perovskite Antioxidant DNA cleavage Antimicrobial |
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