顶空毛细管气相色谱法测定去氧孕烯中有机溶剂残留量

建立了顶空毛细管气相色谱法测定去氧孕烯中残留有机溶剂的方法。色谱柱为DB-624毛细管柱,柱温为程序升温,以氮气为载气,用氢火焰离子化检测器(FID)检测。在实验条件下,甲醇、乙醇、丙酮、正己烷、醋酸乙酯、四氢呋喃、环己烷回收率分别为98.5%、97.9%、97.3%、98.2%、97.2%、97.7%、98.5%%,精密度分别为1.7%、2.0%、1.5%、3.1%、1.5%、1.7%、2.2%。在去氧孕烯原料中只检测出了乙醇、丙酮。本法可快速、准确测定去氧孕烯中残留溶剂含量。

Determination of organic solvent residues in desogestrel by headspace capillary gas chromatography

A method for determining organic solvent residues in desogestrel by headspace capillary gas chromatography was developed.A DB-624 caillary column was applied with nitrogen as carrier gas and FID for detection.Organic solvent residues were separated under gradient temperature.Under experimental conditions, the recoveries of methanol,ethanol,acetone,N-hexane,acetic ether,tetrahydrofuran and hexamethylene were 98.5%,97.9%,97.3%,98.2%,97.2%,97.7%and 98.5%,respectively,and the precisions were 1.7%,2.0%,1.5%,3.1%...