| 中国南海软珊瑚Sinularia sp.细胞的毒活性成分 |
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| 引用本文： | 钟惠民,王现杰,唐旭利,李国强. 中国南海软珊瑚Sinularia sp.细胞的毒活性成分[J]. 青岛科技大学学报(自然科学版), 2009, 30(1) |
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| 作者姓名： | 钟惠民 王现杰 唐旭利 李国强 |
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| 作者单位： | 青岛科技大学,化学与分子工程学院,山东,青岛,266042;中国海洋大学,化学化工学院,山东,青岛,266003;中国海洋大学,海洋药物教育部重点实验室,山东,青岛,266003 |
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| 基金项目： | 国家海洋局908专项课题，海洋药物教育部重点实验室开放基金 |
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| 摘 要： | 运用柱层析和制备高效液相色谱技术,从中国南海软珊瑚Sinularia sp.中分离得到了3个西松烷二萜和2个甾醇成分。利用1D NMR、2D NMR(1H-1HCOSY,HMQC,HMBC)和ESI-MS手段,鉴定它们的结构分别为(1S,2R)-西-松3E,7E,11E,15(17)-四-烯16,2-内酯(1);(1S,2R,7S,8R,11S)-7-乙酰氧基-8,11-环二氧-西松-3E,12E,15(17)?三-烯16,2-内酯(2);(12S,13S)-12,13-环氧-西松-4E,7E,15(17)-三-烯16,2-内酯(3);胆甾-5-烯-3β-醇(4);5,α8α-环二氧-麦角甾-6,22-二烯-3β-醇(5)。化合物(2),(3)显示中等的细胞毒活性。
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| 关 键 词： | 软珊瑚 Sinularia sp. 西松烷二萜 甾醇 |
Studies on Cytotoxic Constituents of Soft Coral Sinularia sp. from the South China Sea |
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| ZHONG Hui-min,WANG Xian-jie,TANG Xu-lia,b,LI Guo-qianga,b. Studies on Cytotoxic Constituents of Soft Coral Sinularia sp. from the South China Sea[J]. Journal of Qingdao University of Science and Technology:Natutral Science Edition, 2009, 30(1) |
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| Authors: | ZHONG Hui-min WANG Xian-jie TANG Xu-lia b LI Guo-qianga b |
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| Affiliation: | 1.College of Chemistry and Molecular Engineering;Qingdao University of Science and Technology;Qingdao 266042;China;2.Ocean University of China a.College of Chemistry and Chemical Engineering;b.Key Laboratory of Marine Drugs;Ministry of Education;Qingdao 266003;China |
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| Abstract: | Three cembraniod diterpenes,(1S,2R)cembr-3E,7E,11E,15(17)-teteraen-16,2-olide(1);(1S,2R,7S,8R,11S)-7-acetyloxy-8,11-epdioxy-cembr-3E,12E,15(17)-trien-16,2-olide(2);(12S,13S)-12,13-epoxy-cembr-4E,7E,15(17)-trien-16,2-olide(3) and two sterols,cholest-5-en-3β-ol(4);5α,8α-epodioxy-ergosta-6,22-dien-3β-ol(5),were isolated from the soft coral Sinularia sp.by repeatedly silicagel chromatography.Their structures were identified by extensive spectroscopic analysis together with the literatures.Compounds(2) and(3) showed moderate cytotoxic activity against the selected tumor lines P-388 and BEL-7402. |
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| Keywords: | Sinularia sp. |
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