Rhodamine-based fluorescent sensor for mercury in buffer solution and living cells |
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| Affiliation: | 1. Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China;2. Emergency Department of Chinese PLA General Hospital, Beijing 100853, PR China;3. Graduate School of Chinese Academy of Sciences, Beijing, PR China;1. College of Environmental Sciences, Liaoning University, Shenyang, 110036, PR China;2. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116012, PR China;3. Liaoning Center of Disease Prevention and Control, Shenyang, 110001, PR China;1. Department of Biochemical Engineering, Nanjing University of Science & Technology, Chemical Engineering Building B308, 200 Xiaolinwei, Nanjing 210094, PR China;2. Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, PR China;3. Department of Chemistry, School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, PR China;4. Department of Nuclear Medicine, The Affiliated Drum Tower Hospital of NanJing University, Zhongshan Road, Nanjing 210008, PR China;1. Research Institute of Pesticidal Design & Synthesis, College of Sciences/Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi Province, People''s Republic of China;2. State Key Laboratory of Crop Stress Biology for Arid Areas, Northwest A&F University, Yangling 712100, Shaanxi Province, People''s Republic of China;1. Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China;2. Department of Ecology and Environment, Yuzhang Normal University, Nanchang 330103, PR China;1. Department of Advanced Organic Materials Engineering, Chungnam National University, Daejeon 305-764, South Korea;2. Department of Biochemistry, Chungnam National University, Daejeon 305-764, South Korea;3. Department of Chemical Engineering, Chungnam National University, Daejeon 305-764, South Korea |
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| Abstract: | A novel fluorescent sensor based on thiooxorhodamine B has been prepared to detect Hg2+ in aqueous buffer solution. It demonstrates high selectivity for sensing Hg2+ with about 383-fold enhancement in fluorescence emission intensity and micromolar sensitivity (Kd = 7.5 × 10?6 mol L?1) in comparison with alkali and alkaline earth metal ions (K+, Na+, Mg2+, Ca2+) and other transition metal ions (Mn2+, Ni2+, Co2+, Cu2+, Zn2+, Cd2+, Ag+, Pb2+, Cr3+, Fe3+). Meanwhile the distinct color changes and rapid switch-on fluorescence also provide ‘naked eyes’ detection for Hg2+ over a broad pH range. Moreover, such sensor is cell-permeable and can visualize the changes of intracellular mercury ions in living cells using fluorescence microscopy. |
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