| 依卡倍特钠的核磁共振数据解析 |
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| 引用本文： | 祝贺,袁延强,孙庆雷,林云良.依卡倍特钠的核磁共振数据解析[J].精细化工中间体,2008,38(5). |
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| 作者姓名： | 祝贺 袁延强 孙庆雷 林云良 |
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| 作者单位： | 1. 山东省分析测试中心,山东,济南,250014
2. 山东省科学院生物所,山东,济南,250014 |
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| 摘 要： | 依卡倍特钠是日本田边公司生产的一种具有覆盖作用的抗胃炎、胃溃疡的新型药物。笔者对依卡倍特钠进行了1H NMR、13C NMR检测,并通过DEPT、gCOSY、gHMQC、gHMBC等2DNMR技术对其NMR数据进行较为详细的解析和NMR信号全归属,为今后的分析鉴定工作提供完善的NMR数据。
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| 关 键 词： | 药物化学 依卡倍特钠 NMR解析 |
Assignment of Chemical Shift of Ecabet Sodium |
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| ZHU He,YUAN Yan-qiang,SUN Qing-lei,LIN Yun-liang.Assignment of Chemical Shift of Ecabet Sodium[J].Fine Chemical Intermediates,2008,38(5). |
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| Authors: | ZHU He YUAN Yan-qiang SUN Qing-lei LIN Yun-liang |
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| Affiliation: | ZHU He1,YUAN Yan-qiang2,SUN Qing-lei1,LIN Yun-liang1(1.Sh,ong Analysis , Test Center,Ji\'nan 250014,China,2.Biology institute of Sh,ong Academy of Science,China) |
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| Abstract: | Ecabet sodium is a new drug for treating gastric ulcer and gastritis invented by JapanTanabe Seiyaku Company.Its major function is to protect gastric mucosal via its adherence to the gastric mucosa,enhancing gastric mucosal defensive ability and the defensive factors such as the endogenous prostaglandins.The 1H NMR and 13C NMR spectra of ecabet sodium were acquired,completely assigned and analyzed by a combination of 1D(1H NMR,13C NMR and DEPT) and 2D NMR(1H-1H COSY,HMQC and HMBC) techniques.The results obt... |
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| Keywords: | medicinal chemistry ecabet sodium NMR analysis |
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